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Orforglipron Side Effects and Safety

Reported Orforglipron side effects, contraindications, and safety signals.

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Compiled from published research · Continuously updated

Common and Serious Risks

As with other GLP-1 receptor agonists, the most common side effects are gastrointestinal — nausea, diarrhea, constipation, and vomiting — typically most pronounced during dose titration. The class boxed warning for medullary thyroid carcinoma risk (based on rodent data) applies. Pancreatitis, gallbladder disease, and pregnancy are contraindications shared across the GLP-1 class.

Contraindications

  • personal/family history of medullary thyroid carcinoma
  • MEN 2
  • pancreatitis
  • pregnancy
All Orforglipron sections

Retatrutide

fat loss & metabolismAgrade

An investigational triple GIP/GLP-1/glucagon receptor agonist producing some of the largest average weight reductions reported for a single agent.

Exenatide

fat loss & metabolismSgrade

The first-in-class GLP-1 receptor agonist, derived from a peptide found in Gila monster saliva — sold as Byetta and Bydureon.

Liraglutide

fat loss & metabolismSgrade

A once-daily GLP-1 receptor agonist — the class predecessor to semaglutide and tirzepatide, still widely prescribed under Victoza and Saxenda.

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