Orforglipron Pharmacokinetics
Orforglipron half-life, absorption, routes of administration, and clearance.
Oral Absorption
Orforglipron is absorbed through the gastrointestinal tract without requiring the specialized absorption-enhancer (SNAC) technology that oral semaglutide depends on, which is what allows it to be dosed without fasting. Its half-life of roughly 29–49 hours supports once-daily oral dosing with steady accumulation over the first 1–2 weeks of a given dose level.
Physicochemical and PK profile
- Half-Life
- ~29–49 hours
- Solubility
- Oral tablet — no reconstitution required
- Storage
- Room temperature, sealed, away from light and moisture. No refrigeration or reconstitution required.