Weight Loss Peptides
GLP-1 and metabolic compounds, graded on the trial evidence behind the weight they actually move.
Retatrutide
An investigational triple GIP/GLP-1/glucagon receptor agonist producing some of the largest average weight reductions reported for a single agent.
Exenatide
The first-in-class GLP-1 receptor agonist, derived from a peptide found in Gila monster saliva — sold as Byetta and Bydureon.
Liraglutide
A once-daily GLP-1 receptor agonist — the class predecessor to semaglutide and tirzepatide, still widely prescribed under Victoza and Saxenda.
Orforglipron
The first oral, non-peptide GLP-1 receptor agonist pill with no food or water restrictions — FDA-approved in 2026 as Foundayo.
Semaglutide
A GLP-1 receptor agonist that reduces appetite and improves glucose control, widely used for weight loss.
Tesamorelin
An FDA-approved GHRH analog known for reducing stubborn visceral fat and raising IGF-1 levels.
Tirzepatide
A dual GIP/GLP-1 receptor agonist offering strong appetite suppression and glucose control, often more potent than semaglutide.
5-Amino-1MQ
An NNMT-inhibiting small molecule studied for fat loss in obese mice — no human trials have been published as of 2026.