REGEN
Get REGENGet Now
LibraryToolsNotesBlogFAQ

5-Amino-1MQ Research Evidence

The 5-Amino-1MQ evidence base: trials, journals, and what the data does not yet show.

RE
Compiled from published research · Last updated 2026-08-18T00:00:00.000Z

Animal Data Only

The primary supporting study (Neelakantan et al., 2018, Bioorg Med Chem Lett) showed that blocking NNMT with 5-Amino-1MQ reduced body weight by roughly 7% and lowered white-fat mass in a diet-induced-obesity mouse model. As of 2026, no human trial of 5-Amino-1MQ has been published — the entire efficacy case rests on this and related animal extrapolation.

Regulatory and Legal Status

5-Amino-1MQ is not FDA-approved for any indication and is sold exclusively as a research-grade compound (RUO). Researchers and users should verify the legal status of 5-Amino-1MQ in their jurisdiction prior to purchase or use, and should weigh the complete absence of human trial data accordingly.

Trials and reviews

  • Neelakantan diet-induced obesityBioorg Med Chem Lett2018

    -7% body weight in obese mice; zero published human trials

References

  1. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice · Neelakantan H, et al. · 2018
All 5-Amino-1MQ sections

NAD+

recovery & wellnessCgrade

A naturally occurring cellular coenzyme central to energy metabolism and DNA repair — sold as an IV, injectable, and oral longevity supplement.

MOTS-c

longevity & healthspanCgrade

A mitochondrial-derived peptide that supports metabolic flexibility, insulin sensitivity, and exercise capacity.

Retatrutide

fat loss & metabolismAgrade

An investigational triple GIP/GLP-1/glucagon receptor agonist producing some of the largest average weight reductions reported for a single agent.

Put the whole protocol
in one place.

Download nowGet Now