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5-Amino-1MQ Mechanism of Action

How 5-Amino-1MQ works: receptor targets, signalling pathways, and molecular profile.

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Compiled from published research · Last updated 2026-08-18T00:00:00.000Z

Blocking NNMT to Change Fat-Cell Metabolism

5-Amino-1MQ inhibits NNMT (nicotinamide N-methyltransferase), an enzyme highly expressed in fat tissue that methylates nicotinamide, consuming a methyl-donor pool the cell would otherwise use for other metabolic processes. NNMT activity has been linked to fat-cell energy storage and to obesity in human observational data, which is the rationale for studying its inhibition as a fat-loss strategy.

Not a Peptide

Unlike most compounds in this catalog, 5-Amino-1MQ is a small molecule, not a peptide — structurally unrelated to amino-acid chains. It's grouped in the same research-vendor and longevity-community conversation as NAD+ and MOTS-c because of shared interest in metabolic/mitochondrial health, not because of any structural similarity.

References

  1. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice · Neelakantan H, et al. · 2018
All 5-Amino-1MQ sections

NAD+

recovery & wellnessCgrade

A naturally occurring cellular coenzyme central to energy metabolism and DNA repair — sold as an IV, injectable, and oral longevity supplement.

MOTS-c

longevity & healthspanCgrade

A mitochondrial-derived peptide that supports metabolic flexibility, insulin sensitivity, and exercise capacity.

Retatrutide

fat loss & metabolismAgrade

An investigational triple GIP/GLP-1/glucagon receptor agonist producing some of the largest average weight reductions reported for a single agent.

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