NAD+ Research Evidence
The NAD+ evidence base: trials, journals, and what the data does not yet show.
Evidence Base
Most human evidence on raising NAD+ levels comes from studies of oral precursors (NMN, NR) rather than direct NAD+ administration, and even that literature is still early — small trials, short durations, and mixed results on hard clinical endpoints. Claims around IV/injectable NAD+ for energy, cognition, or longevity are largely anecdotal and clinic-marketed rather than backed by controlled human trials.
Regulatory and Legal Status
Oral NAD+ is available over-the-counter as a dietary supplement in the US. Injectable and IV NAD+ are typically compounded and administered at wellness clinics; the FDA has scrutinized NAD+ in recent compounding rulemaking discussions. NAD+ is not an FDA-approved drug for any indication, and longevity/anti-aging claims made about it have not been FDA-evaluated. Verify local compounding-pharmacy regulations before pursuing injectable/IV administration.