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Sermorelin Side Effects and Safety

Reported Sermorelin side effects, contraindications, and safety signals.

RE
Compiled from published research · Last updated 2026-07-24T00:00:00.000Z

Well-Characterized, Generally Mild

Given its history as an approved drug, sermorelin has a comparatively well-characterized safety profile among GH secretagogues — injection-site flushing, headache, and dizziness are the most commonly reported effects. Active malignancy is a precautionary contraindication given the downstream IGF-1 stimulation shared across the GH-secretagogue class.

Contraindications

  • active malignancy
  • pregnancy

References

  1. Khorram GHRH(1-29) body composition study · Khorram O, et al. · 1997
All Sermorelin sections

Ipamorelin

growth & GHCgrade

A selective GH secretagogue (ghrelin mimetic) that raises growth hormone with minimal effect on cortisol or appetite.

hCG (Human Chorionic Gonadotropin)

growth & hormonesSgrade

An FDA-approved hormone that mimics LH, restoring the body's own testosterone and sperm production — the label dates to 1962.

Tesamorelin + Ipamorelin Blend

growth & GHBgrade

A single-vial blend pairing FDA-approved GHRH analog Tesamorelin with the selective ghrelin-agonist Ipamorelin for a combined GH pulse in one injection.

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