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Sermorelin Dosage and Protocols

Sermorelin dosage protocols reported in published research, plus reconstitution and storage.

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Compiled from published research · Last updated 2026-07-24T00:00:00.000Z

Pre-Bed Dosing

Research-typical dosing is 200–300mcg subcutaneous once daily, timed before bed to align with the body's natural nighttime GH pulse — mirroring how sermorelin was dosed during its FDA-approved Geref era.

Reported protocol doses

Standard dose200–300 mcg
Frequencypre-bed
Routessubcutaneous

Reconstitution

A 5mg vial with 2mL of bacteriostatic water is the pairing reported most often. 5mg vial + 2mL bacteriostatic water = 2500mcg/mL.

Work out your own concentration with the reconstitution calculator.

Doses shown are those reported in published research, not a recommendation.

References

  1. Khorram GHRH(1-29) body composition study · Khorram O, et al. · 1997
All Sermorelin sections

Ipamorelin

growth & GHCgrade

A selective GH secretagogue (ghrelin mimetic) that raises growth hormone with minimal effect on cortisol or appetite.

hCG (Human Chorionic Gonadotropin)

growth & hormonesSgrade

An FDA-approved hormone that mimics LH, restoring the body's own testosterone and sperm production — the label dates to 1962.

Tesamorelin + Ipamorelin Blend

growth & GHBgrade

A single-vial blend pairing FDA-approved GHRH analog Tesamorelin with the selective ghrelin-agonist Ipamorelin for a combined GH pulse in one injection.

Put the whole protocol
in one place.

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