hCG (Human Chorionic Gonadotropin) Research Evidence
The hCG (Human Chorionic Gonadotropin) evidence base: trials, journals, and what the data does not yet show.
A Six-Decade-Old FDA Label
hCG's FDA approval for hypogonadotropic hypogonadism and fertility use dates back to 1962 — one of the oldest, most established hormone therapies in this catalog. In a 2019 study (Madhusoodanan et al., n=20) of men taking hCG as monotherapy, testosterone rose approximately 50%, with roughly half reporting symptom improvement — low libido and erectile dysfunction were each the presenting complaint in 45% of participants.
Regulatory and Legal Status
hCG is prescription-only and FDA-approved, with an exceptionally long track record. It should be obtained through a licensed prescriber and pharmacy. Note: the popular 'hCG diet' (very-low-calorie dieting combined with hCG for weight loss) is not part of hCG's approved label or supported by its evidence base — the FDA has specifically warned against marketing hCG for weight loss.
Trials and reviews
- Madhusoodanan hCG monotherapyclinical study2019
Testosterone rose ~50% on hCG alone (n=20)
References
- hCG monotherapy for hypogonadism · Madhusoodanan V, et al. · 2019