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hCG (Human Chorionic Gonadotropin) Dosage and Protocols

hCG (Human Chorionic Gonadotropin) dosage protocols reported in published research, plus reconstitution and storage.

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Compiled from published research · Last updated 2026-07-24T00:00:00.000Z

TRT-Adjacent Dosing

TRT-adjacent protocols commonly dose hCG at 250–500 IU subcutaneous, 2-3 times weekly — lower and more frequent than the larger doses used for fertility-induction protocols, which are prescriber-directed and higher.

Reported protocol doses

Standard dose250–500 IU
Frequency2–3x weekly
Routessubcutaneous, intramuscular

Reconstitution

A 5000mg vial with 5mL of bacteriostatic water is the pairing reported most often. 5,000 IU vial + 5mL bacteriostatic water = 1000 IU/mL. A 250 IU dose is 0.25mL (25 units on an insulin syringe).

Work out your own concentration with the reconstitution calculator.

Doses shown are those reported in published research, not a recommendation.

References

  1. hCG monotherapy for hypogonadism · Madhusoodanan V, et al. · 2019
All hCG (Human Chorionic Gonadotropin) sections

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