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Oxytocin Pharmacokinetics

Oxytocin half-life, absorption, routes of administration, and clearance.

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Compiled from published research · Continuously updated

Extremely Rapid Clearance

Oxytocin has a plasma half-life of roughly 3–5 minutes, rapidly broken down by the enzyme oxytocinase. This very short half-life is why IV administration for labor requires a continuous infusion rather than a single bolus, and why intranasal research protocols are timed shortly before the activity of interest.

Physicochemical and PK profile

Molecular Formula
C43H66N12O12S2
Molecular Weight
1007.19 g/mol
CAS Number
50-56-6
Half-Life
~3-5 minutes
Storage
Store the lyophilized vial refrigerated (2-8°C) or at -20°C, away from light. Once reconstituted, keep refrigerated at 2-8°C and use promptly.
All Oxytocin sections

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