CJC-1295 (DAC) Stacking and Combinations
Which compounds CJC-1295 (DAC) is paired with, and the rationale behind each combination.
Synergistic GHRP Combination
Extensive research demonstrates that CJC-1295 produces synergistic effects when combined with growth hormone releasing peptides such as Ipamorelin or GHRP-6, resulting in substantially greater GH release than either compound alone. This synergy occurs because CJC-1295 acts on GHRH receptors while GHRPs act on ghrelin receptors, activating complementary pathways that amplify pituitary GH secretion. Studies document 2-5 fold greater GH release with combined administration compared to either peptide individually. This combination approach has become a standard research protocol for studying maximized natural GH secretion, optimal body composition effects, and the potential therapeutic applications of enhanced GH/IGF-1 axis activation.
Commonly paired with
- Ipamorelin — A selective GH secretagogue (ghrelin mimetic) that raises growth hormone with minimal effect on cortisol or appetite.
References
- Prolonged stimulation of growth hormone and IGF-I secretion by CJC-1295 · Teichman SL, et al. · 2006
- Teichman SL, et al. Prolonged Stimulation of Growth Hormone (GH) and Insulin-Like Growth Factor I Secretion by CJC-1295, a Long-Acting Analog of GH-Releasing Hormone, in Healthy Adults. Journal of Clinical Endocrinology & Metabolism. 2006;91(3):799-805. · Hoffmann P, Feige JJ, Alfaidy N · 2006
- Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. · Sackmann-Sala L, Ding J, Frohman LA et al. · 2009
- Jette L, et al. Human Growth Hormone-Releasing Factor (hGRF)1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog. Endocrinology. 2005. · Chung S, Son GH, Park SH, Park E, Lee KH, Geum D, Kim K · 2005
- Alba M, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology-Endocrinology and Metabolism. 2006. · Zaidi D, James KA, Wagner GF · 2006
- Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. · Ionescu M, Frohman LA · 2006