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Semaglutide Dosage and Protocols

Semaglutide dosage protocols reported in published research, plus reconstitution and storage.

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Compiled from published research · 1 min read · 6 references · Last updated August 18, 2026

Dosing Summary

Dosing details above reflect FDA-approved labeling and/or published clinical protocols. Always refer to the official drug label (linked above) for approved prescribing details, contraindications, and warnings.

Reported protocol doses

Standard dose0.25–2.4 mg
Frequency1x weekly (titrated)
Routessubcutaneous, oral

Reconstitution

A 5mg vial with 2mL of bacteriostatic water is the pairing reported most often. 5mg vial + 2mL bacteriostatic water = 2500mcg/mL. Start at 0.25mg (0.1mL / 10 units) weekly and titrate up no faster than every 4 weeks.

Work out your own concentration with the reconstitution calculator.

Doses shown are those reported in published research, not a recommendation.

References

  1. Once-Weekly Semaglutide in Adults with Overweight or Obesitypubmed.ncbi.nlm.nih.gov · Wilding JPH, et al. · 2021
  2. FDA Approval Announcement for Wegovy (2021).fda.gov · 2021
  3. Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes.pubmed.ncbi.nlm.nih.gov · Lincoff AM, Brown-Frandsen K, Colhoun HM et al. · 2023
  4. Semaglutide, a glucagon like peptide-1 receptor agonist with ... - NIHpmc.ncbi.nlm.nih.gov · Mahapatra MK, Karuppasamy M, Sahoo BM · 2022
  5. Semaglutide Mechanism of Action Review. PMC.ncbi.nlm.nih.gov · Ghusn W, De la Rosa A, Sacoto D, Cifuentes L, Campos A, Feris F, Hurtado MD, Acosta A · 2022
  6. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes.pubmed.ncbi.nlm.nih.gov · McGuire DK, Marx N, Mulvagh SL et al. · 2025
All Semaglutide sections

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A-grade

An investigational triple GIP/GLP-1/glucagon receptor agonist producing some of the largest average weight reductions reported for a single agent.

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Exenatide

S-grade

The first-in-class GLP-1 receptor agonist, derived from a peptide found in Gila monster saliva, sold as Byetta and Bydureon.

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Liraglutide

S-grade

A once-daily GLP-1 receptor agonist, the class predecessor to semaglutide and tirzepatide, still widely prescribed under Victoza and Saxenda.

Weight LossFDA-approved

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