MK-677 Pharmacokinetics
MK-677 half-life, absorption, routes of administration, and clearance.
Oral Absorption and a 24-Hour Half-Life
MK-677's defining pharmacokinetic feature is that it is orally bioavailable and long-acting, the property that separates it from every injectable secretagogue in this library. • Oral Tmax is approximately 30 minutes to 2 hours, with a terminal elimination half-life of approximately 24 hours, dramatically longer than Ipamorelin's ~2 hours or GHRP-6's ~1 hour. • Because of this long half-life, once-daily oral dosing maintains meaningfully elevated growth hormone and IGF-1 levels across the full 24-hour period rather than producing one discrete pulse, and IGF-1 in particular stays elevated between doses due to its own longer physiological half-life. • No injection or reconstitution is required, MK-677 is dosed as an oral capsule or solution, which is the practical basis for its popularity as a lower-friction alternative to injectable GH secretagogues.
Physicochemical and PK profile
- Molecular Formula
- C27H36N4O5S
- Molecular Weight
- 528.67 g/mol
- CAS Number
- 159752-10-0
- Half-Life
- Approximately 24 hours
- Solubility
- Oral capsule/solution, no reconstitution required
- Storage
- Store capsules/solution at room temperature, away from light and moisture.
References
- MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.
- Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.
- Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.
- Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women.
- Ibutamoren | C27H36N4O5S | CID 9576836 - PubChem - NIH