GHRP-6 Side Effects and Safety
Reported GHRP-6 side effects, contraindications, and safety signals.
Safety & Contraindications
GHRP-6 is a research compound and is not FDA-approved for general use. It should be avoided by anyone with active malignancy and pregnancy. Most reported effects are mild and dose-dependent, so start at the low end of the dosing range and titrate up slowly rather than chasing a maximal dose. Injection-site redness, itching, or a temporary lump are the most common local reactions; rotate sites and use clean technique to keep them minimal.
What to Monitor
Track prolactin, IGF-1, and fasting glucose while you're running GHRP-6 so you can catch any drift early and adjust before it becomes a problem. Add these to your REGEN biomarker dashboard and re-check on your normal cadence.
Contraindications
- active malignancy
- pregnancy
References
- GHRP-6 and the discovery of the ghrelin receptor · Bowers CY · 2012
- Bowers CY, et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 1984;114(5):1537-1545. · Bowers CY, Momany FA, Reynolds GA, Hong A · 1984
- Acute dexamethasone administration enhances GH responsiveness to GH releasing peptide-6 (GHRP-6) in man. · Pinto AC, Finamor FE Jr, Lengyel AM · 1999
- Howard AD, et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science. 1996;273(5277):974-977. · Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH · 1996
- Growth hormone response to GHRH, GHRP-6 and GHRH + GHRP-6 in patients with polycystic ovary syndrome. · Micić D, Kendereski A, Popović V et al. · 1996
- Synthetic Growth Hormone-Releasing Peptides (GHRPs) - NIH · Berlanga-Acosta J, Abreu-Cruz A, Herrera DGB, Mendoza-Marí Y, Rodríguez-Ulloa A, García-Ojalvo A, Falcón-Cama V, Hernández-Bernal F, Beichen Q, Guillén-Nieto G · 2017