Thymosin Alpha-1 Pharmacokinetics
Thymosin Alpha-1 half-life, absorption, routes of administration, and clearance.
Short Half-Life Supporting Twice-Weekly Dosing
Thymosin Alpha-1 has a plasma half-life of approximately 2 hours, though its immunomodulatory effects — driven by downstream immune-cell signaling rather than sustained receptor occupancy — persist well beyond the compound's direct circulating presence, consistent with its twice-weekly clinical dosing schedule.
Physicochemical and PK profile
- Molecular Formula
- C129H215N33O55
- Molecular Weight
- 3108.3 g/mol
- CAS Number
- 62304-98-7
- Half-Life
- ~2 hours
- Storage
- Store the lyophilized vial refrigerated (2-8°C) or at -20°C, away from light. Once reconstituted, keep refrigerated at 2-8°C and use promptly.
References
- Thymosin-α1 for people with chronic hepatitis B (Cochrane Review CD014610) · Htet NH, et al. · 2022