SLU-PP-915 Mechanism of Action
How SLU-PP-915 works: receptor targets, signalling pathways, and molecular profile.
The Same ERR Mechanism, Now Oral
SLU-PP-915 activates the same pan-ERR (estrogen-related receptor) pathway as its predecessor SLU-PP-332, driving the PGC-1α-linked mitochondrial biogenesis and fatty-acid oxidation gene program associated with endurance exercise. Its defining engineering achievement is retaining this activity when dosed orally — SLU-PP-332 required injection to show effects in mice.
Exercise Capacity, Not Just Metabolic Markers
SLU-PP-915's headline mouse result is functional, not just biochemical: increased treadmill exercise capacity, in a dose-dependent way, that held up when the compound was given orally — a more direct performance readout than the fat-mass/gene-expression endpoints emphasized in SLU-PP-332's data.
References
- SLU-PP-915 orally-active ERR agonist exercise study · Billon C, et al. · 2025