MOTS-c Pharmacokinetics
MOTS-c half-life, absorption, routes of administration, and clearance.
Half-Life & Dosing Cadence
MOTS-c has a reported elimination half-life of ~3-4 hours. The half-life is the time it takes for blood levels to fall by half, and it's the single biggest driver of how often you dose. That's why the typical schedule lands around 2-3x weekly at 5–10 mg — frequent enough to keep levels in a useful range without stacking up. Shorter half-lives mean more frequent dosing and faster clearance if you stop; longer ones mean steadier levels but a slower washout.
Administration & Absorption
MOTS-c is administered by subcutaneous injection (into the fat layer just under the skin). The primary route is subcutaneous. Subcutaneous delivery is absorbed steadily from the fat depot, giving smoother peaks than intramuscular dosing. Whichever route you use, rotate sites and follow sterile technique.
Reconstitution & Handling
MOTS-c ships as a lyophilized (freeze-dried) powder that you reconstitute before use — a common starting point is a 10 mg vial with 2 mL of bacteriostatic water. Add the water slowly down the vial wall, swirl (don't shake), and let it fully dissolve. Reconstituted peptide is refrigerated and used within its stability window; unmixed powder keeps far longer when stored cold and dark. Always confirm exact dosing math against your own vial and concentration.
Onset & Clearance
Because of its ~3-4 hours half-life, MOTS-c reaches steady levels after a few consistent doses and clears the system within roughly four to five half-lives once you stop. Track how you respond over a defined block rather than judging any single dose, and give the compound enough consistent days before deciding whether it's working. This is educational information, not medical advice — review your protocol with a clinician.
Physicochemical and PK profile
- Molecular Formula
- C101H152N28O22S2
- Molecular Weight
- 2174.59 g/mol
- CAS Number
- 1627580-64-6
- Half-Life
- Not precisely established
- Sequence
- MRWQEMGYIFYPRKLR
- Solubility
- Soluble in water
- Storage
- Store at -20°C.
References
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis · Lee C, et al. · 2015
- ClinicalTrials.gov: A Phase 1a/1b Study of CB4211 in Healthy Non-obese Subjects and Subjects With Nonalcoholic Fatty Liver Disease
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of ...
- Mots-c | C101H152N28O22S2 | CID 146675088 - PubChem
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the ...
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation · Zheng Y, Wei Z, Wang T · 2023
- Mitochondria-derived peptide MOTS-c: effects and mechanisms ... · Wan W, Zhang L, Lin Y, Rao X, Wang X, Hua F, Ying J · 2023
- MOTS-c Functionally Prevents Metabolic Disorders · Gao Y, Wei X, Wei P, Lu H, Zhong L, Tan J, Liu H, Liu Z · 2023
- The mitochondrial-derived peptide MOTS-c relieves hyperglycemia ... · Yin Y, Pan Y, He J, Zhong H, Wu Y, Ji C, Liu L, Cui X · 2022
- MOTS-c: an equal opportunity insulin sensitizer - PMC · Kim SJ, Miller B, Kumagai H, Yen K, Cohen P · 2019
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to ... - NIH · Kim KH, Son JM, Benayoun BA, Lee C · 2018
- MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus - PMC · Benayoun BA, Lee C · 2019