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Humanin Side Effects and Safety

Reported Humanin side effects, contraindications, and safety signals.

RE
Compiled from published research · 1 min read · 1 reference · Last updated July 24, 2026
Safety

No Human Safety Data

Because no human trial exists, humanin has no characterized human side-effect profile. Active malignancy is treated as a precautionary contraindication given its cytoprotective mechanism, which theoretically could protect damaged cells indiscriminately.

Contraindications

  • pregnancy
  • active malignancy

References

  1. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abetapubmed.ncbi.nlm.nih.gov · Hashimoto Y, et al. · 2001
All Humanin sections

MOTS-c

C-grade

A mitochondrial-derived peptide that supports metabolic flexibility, insulin sensitivity, and exercise capacity.

MetabolismInsulin

Thymosin Alpha-1

A-grade

A 28-amino-acid thymic peptide approved in 35+ countries as Zadaxin for immune support, but never FDA-approved in the United States.

Immune SupportLongevity

Oxytocin

B-grade

A naturally occurring nonapeptide, FDA-approved as Pitocin for labor, and separately studied off-label (intranasal) for social bonding and stress research.

Bonding & SocialFDA-approved

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