Melanotan I (Afamelanotide) Pharmacokinetics
Melanotan I (Afamelanotide) half-life, absorption, routes of administration, and clearance.
Short Circulating Half-Life, Implant Extends Duration
Free afamelanotide has a short plasma half-life of roughly 30-50 minutes; the FDA-approved implant achieves its roughly month-long duration of effect through sustained-release delivery from the implant itself, not from the peptide's intrinsic pharmacokinetics.
Physicochemical and PK profile
- Half-Life
- ~30-50 minutes
- Storage
- Store the lyophilized vial refrigerated (2-8°C) or at -20°C, away from light. Once reconstituted, keep refrigerated at 2-8°C and use promptly.
References
- Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo · Lim HW, et al. · 2015