MOTS-c reconstitution calculator.
Pre-filled with the 10 mg vial and 2 mL of bacteriostatic water the REGEN catalog reports for MOTS-c. Every field is editable.
The numbers for a 10 mg MOTS-c vial
Reconstituting a 10 mg vial with 2 mL of bacteriostatic water gives a concentration of 5 mg/mL. On a U-100 insulin syringe, where one unit is 0.01 mL, that puts 50 mcg in every unit drawn.
A 5000 mcg dose at that concentration is 1 mL, which is 100 units on the syringe, and the vial holds about 2 of them.
Those are the values the calculator above opens with. The vial size and water volume are the amounts the REGEN catalog reports for MOTS-c; change any field and the arithmetic follows.
What the research reports for MOTS-c
Published protocols for MOTS-c report 5–10 mg, 2-3x weekly. That is what the literature describes, not a recommendation. The calculator starts at the low end of it. The MOTS-c reference page carries the evidence grade, the side-effect profile, and the primary sources behind that range.
MOTS-c reconstitution chart for a 10 mg vial
The same 10 mg of MOTS-c at four common water volumes. More water does not mean more compound, it spreads the same amount across a bigger volume, so the same dose is drawn to a higher number of units. That is usually the safer direction to be imprecise in: small errors on a longer draw matter proportionally less.
| Bacteriostatic water | Concentration | Per unit (U-100) | Units for 5000 mcg |
|---|---|---|---|
| 1 mL | 10 mg/mL | 100 mcg | 50 units |
| 2 mL (catalog) | 5 mg/mL | 50 mcg | 100 units |
| 3 mL | 3.33 mg/mL | 33.3 mcg | 150 units |
| 5 mL | 2 mg/mL | 20 mcg | 250 units |
"Units" here means syringe graduations, not international units. They are unrelated measures that share a name, and conflating them is its own category of mistake. The reconstitution calculator explains the arithmetic behind these columns in full.
More on MOTS-c
The MOTS-c reference page covers how it works, what the research grade means, side effects, and pharmacokinetics, alongside the rest of the longevity compounds. For a different compound, the generic reconstitution calculator takes any vial and dose.