Larazotide Pharmacokinetics
Larazotide half-life, absorption, routes of administration, and clearance.
Designed for Local, Not Systemic, Action
Larazotide's mechanism depends on acting locally within the gut lumen at the tight-junction level, rather than systemic absorption and circulation — a conventional plasma half-life isn't the relevant pharmacokinetic parameter here the way it is for injectable peptides.
Physicochemical and PK profile
- Solubility
- Oral capsule — no reconstitution required
- Storage
- Room temperature, sealed, away from light and moisture. No refrigeration or reconstitution required.
References
- Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet · Leffler DA, et al. · 2015