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Selank Research Evidence

The Selank evidence base: trials, journals, and what the data does not yet show.

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Compiled from published research · 1 min read · 12 references · Last updated August 18, 2026

Key Findings at a Glance

  • Selank is a synthetic analog of the immune peptide tuftsin with an added Pro-Gly-Pro sequence that dramatically increases its stability and half-life in the body. • Selank is approved in Russia as an anxiolytic medication, making it one of very few peptides prescribed specifically for anxiety disorders in any country. • Research shows Selank modulates the expression of over 50 genes related to inflammation and immune response, suggesting effects far beyond simple anxiety reduction. • Selank influences GABA-ergic neurotransmission without the sedation, tolerance, or dependence typically seen with conventional GABA-enhancing anxiolytics like benzodiazepines.

Trials and reviews

  • Russian PK + tolerabilityEksp Klin Farmakol2014

    favorable safety profile, 20+ years clinical use in RU · review

  • Zozulia anxiolytic trialZh Nevrol Psikhiatr2008

    anxiolytic effect comparable to medazepam, without sedation · N=60

References

  1. Efficacy and safety of Selank in generalized anxiety disorderpubmed.ncbi.nlm.nih.gov · Zozulya AA, et al. · 2008
  2. Zozulya AA, Sizov SV, Syrtsev AV. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48.pubmed.ncbi.nlm.nih.gov · Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB · 2008
  3. [Optimization of the treatment of anxiety disorders with selank].pubmed.ncbi.nlm.nih.gov · Medvedev VE, Tereshchenko ON, Kost NV et al. · 2015
  4. Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027.pmc.ncbi.nlm.nih.gov · Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M · 2017
  5. Rapid and slow response during treatment of generalized anxiety ...sciencedirect.com
  6. Zozulya AA, Kost NV, Sokolov OY, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22.pubmed.ncbi.nlm.nih.gov · Medvedev VE, Tereshchenko ON, Israelian AIu, Chobanu IK, Kost NV, Sokolov OIu, Miasoedov NF · 2014
  7. The optimizing action of the synthetic peptide Selank on a ... - PubMedpubmed.ncbi.nlm.nih.gov · Kozlovskii II, Danchev ND · 2003
  8. Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31.pmc.ncbi.nlm.nih.gov · Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P · 2016
  9. Functional Connectomic Approach to Studying Selank and Semax Effects.pubmed.ncbi.nlm.nih.gov · Panikratova YR, Lebedeva IS, Sokolov OY et al. · 2020
  10. [Experimental optimization of learning and memory processes by ...pubmed.ncbi.nlm.nih.gov · Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM · 2010
  11. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].pubmed.ncbi.nlm.nih.gov · Uchakina ON, Uchakin PN, Miasoedov NF et al. · 2008
  12. Kolomin T, Shadrina M, Slominsky P, et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011;170(1-3):18-23.pubmed.ncbi.nlm.nih.gov · Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N · 2011
All Selank sections

Adamax

F-grade

A synthetic nonapeptide analog of Semax with N-terminal acetylation and adamantyl C-terminal modification, studied for enhanced BDNF signaling and blood-brain barrier penetration.

Cognitive EnhancementNeuroprotection

Semax

B-grade

A Russian nootropic peptide derived from ACTH that supports focus, memory, and neuroprotection by raising BDNF.

Focus & MemoryClarity

Dihexa

F-grade

An oral angiotensin IV analog studied as a memory aid in rodents, the foundational animal paper now carries a formal notice of concern, and no human trial exists.

Cognitive EnhancementNeurogenesis

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