Selank Research Evidence
The Selank evidence base: trials, journals, and what the data does not yet show.
Key Findings at a Glance
• Selank is a synthetic analog of the immune peptide tuftsin with an added Pro-Gly-Pro sequence that dramatically increases its stability and half-life in the body. • Selank is approved in Russia as an anxiolytic medication, making it one of very few peptides prescribed specifically for anxiety disorders in any country. • Research shows Selank modulates the expression of over 50 genes related to inflammation and immune response, suggesting effects far beyond simple anxiety reduction. • Selank influences GABA-ergic neurotransmission without the sedation, tolerance, or dependence typically seen with conventional GABA-enhancing anxiolytics like benzodiazepines.
Trials and reviews
- Russian PK + tolerabilityEksp Klin Farmakol2014
favorable safety profile, 20+ years clinical use in RU · review
- Zozulia anxiolytic trialZh Nevrol Psikhiatr2008
anxiolytic effect comparable to medazepam, without sedation · N=60
References
- Efficacy and safety of Selank in generalized anxiety disorder · Zozulya AA, et al. · 2008
- Zozulya AA, Sizov SV, Syrtsev AV. Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48. · Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB · 2008
- [Optimization of the treatment of anxiety disorders with selank]. · Medvedev VE, Tereshchenko ON, Kost NV et al. · 2015
- Kasian A, Kolomin T, Andreeva L, et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behav Neurol. 2017;2017:5091027. · Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M · 2017
- Rapid and slow response during treatment of generalized anxiety ...
- Zozulya AA, Kost NV, Sokolov OY, et al. A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders. Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(7):17-22. · Medvedev VE, Tereshchenko ON, Israelian AIu, Chobanu IK, Kost NV, Sokolov OIu, Miasoedov NF · 2014
- The optimizing action of the synthetic peptide Selank on a ... - PubMed · Kozlovskii II, Danchev ND · 2003
- Volkova A, Shadrina M, Kolomin T, et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31. · Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P · 2016
- Functional Connectomic Approach to Studying Selank and Semax Effects. · Panikratova YR, Lebedeva IS, Sokolov OY et al. · 2020
- [Experimental optimization of learning and memory processes by ... · Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM · 2010
- [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. · Uchakina ON, Uchakin PN, Miasoedov NF et al. · 2008
- Kolomin T, Shadrina M, Slominsky P, et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul Pept. 2011;170(1-3):18-23. · Kolomin T, Shadrina M, Andreeva L, Slominsky P, Limborska S, Myasoedov N · 2011